Searching for a diagnostic marker and identification of important cell groups in non-IgE mediated gastrointestinal diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19580
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: Waseda University
• Principal Investigator: Orihara Kanami 早稲田大学, 理工学術院, 講師(任期付) (60450623)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 好酸球性消化管疾患 / 非IgE依存性食物タンパク質誘発性胃腸炎 / リンパ球刺激試験

Outline of Final Research Achievements

Non-IgE-mediated eosinophilic gastrointestinal diseases are the diseases that the number of patients continues to increase all over the world, pathology of which in particular in neonates to infants is difficult to distinguish from other diseases. Thus, sometimes it causes life-thretening serious complications.
Therefore, in this study, we aimed to test the practical utility of the antigen-specific lymphocyte stimulation test, which is conducted at the research level at the moment, if it can be clinically applied to the diagnosis of these diseases. As a result, it was confirmed that it can be used for diagnosis, whereas weakness remains in distinguishing these diesases from IgE-mediated (normal) food allergy. I also examined cytokines and proliferating cell sub-popiulations as applied analysis versions of antigen specific lymphocyte tests, and I was able to find differences between IgE-mediated food allergy and non-IgE-mediated eosinophilic gastrointestinal diseases.

Free Research Field

免疫学、アレルギー学、分子生物学、時間生物学