Revival use of existing antibiotics for antimicrobial resistant organisms

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19585
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Infectious disease medicine
• Research Institution: Osaka University
• Principal Investigator: Hagiya Hideharu 大阪大学, 医学部附属病院, 助教 (30718531)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: カルバペネム耐性腸内細菌科細菌 / セファマイシン / セフメタゾール / メロペネム / 併用療法

Outline of Final Research Achievements

Antimicrobial resistance, especially carbapenemase-producing Enterobacteriaceae (CPE), is an ongoing problem that globally undermines medical settings. Considering the high cost of developing new classes of antibiotics, “revival use” of existing antimicrobial agents provides another option to combat the highly resistant microorganisms. In this study, we assessed in vitro efficacy of combination therapy with meropenem and cefmetazole against various carbapenemase-producing Enterobacteriaceae. We applied standard checkerboard and time-kill assays, and revealed a therapeutic possibility of this new combination therapy. Further research on the pharmacokinetic and pharmacodynamics utility, as well as optimal therapeutic regimen and clinical outcomes, should be warranted.

Free Research Field

感染症治療