The effect of ER stress against atopic asthma in airway epithelial cells

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19606
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: University of Fukui
• Principal Investigator: MURAI HIROKI 福井大学, 学術研究院医学系部門, 助教 (50464566)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ER ストレス / 気道上皮細胞 / アレルギー

Outline of Final Research Achievements

We have hypothesized that ER stress may control the severity of asthma, both in the onset and exacerbation. To prove this hypothesis, we used two different inhaled allergens which have both association to asthma. We stimulated airway epithelial cells with house dust mite allergen, however, there were no elicitation of ER pathway both in protein and DNA levels. We next tried whether this stimulation may occur in Th2 condition, however, no excitation of ER pathway was observed under the existence of IL4 or IL13. We stimulated airway epithelial cells with Alternaria, however, no ER stress pathway was increased. These results may suppose that the alermin secretion may be independent of ER pathway.

Free Research Field

アレルギー