2016 Fiscal Year Final Research Report
Early diagnosis of systemic junevnile idiopathic arthritis
| Project/Area Number |
15K19623
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 全身型若年性特発性関節炎 / 早期診断 / 遺伝子発現 / 有核赤血球 / 末梢血単核球 / フローサイトメトリー |
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| Outline of Final Research Achievements |
To establish the diagnostic method for systemic idiopathic juvenile arthritis (JIA), we investigated genes specifically expressed in systemic JIA patients by analyzing whole transcriptome using microarray analysis of peripheral blood mononuclear cells (PBMC). The most upregulated genes (ASHP, HBD, CA1) were derived from nucleated red blood cells (nRBC), which indicated the increased number of nRBC in PBMC. The peripheral blood erythroblastosis of systemic JIA patients was confirmed by flow cytometry.
The analysis of nRBC ratio in PBMC by flow cytometry would be helpful for diagnosis of systemic JIA.
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| Free Research Field |
小児血液・免疫
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