Analyzing ganglioside expression of cutaneous malignant lymphoma

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19688
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Osaka University
• Principal Investigator: KIYOHARA EIJI 大阪大学, 医学系研究科, 助教 (70423176)
• Research Collaborator: MATSUMURA CHIKA ; TAKATA YOKO
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 皮膚悪性リンパ腫 / ガングリオシド / GD3 / GD3 synthase / 菌状息肉症

Outline of Final Research Achievements

Gangliosides have important roles in promoting growth of several tumors. However, there is few reports of ganglioside expression in cutaneous lymphoma. GD3, which is one of the gangliosides, is known to promote growth of tumors. GD3 synthase which can synthesize GD3 from GM3, was increased on lymphoma cell lines. Next, GD3 expression on tumor cells, which were collected from tumors of mycosis fungoides patients, was analyzed. This analysis showed that GD3 on the tumor cells was significantly increased, compared with blood cells of healthy donors. This result implied ganglioside might have important role in cutaneous lymphoma. To show possibility of new target of treatment, we tested apoptosis of lymphoma cell lines, caused by anti-GD3 synthase treatment. However, suppression level of tumor growth was not enough. Taken together, further analysis of ganglioside will be needed in cutaneous lymphoma.

Free Research Field

皮膚悪性腫瘍