Physiological Analysis of Skin-Resident B cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19702
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Keio University
• Principal Investigator: Adachi Takeya 慶應義塾大学, 医学部(信濃町), 訪問助教 (30573258)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 皮膚在住メモリーT細胞 / 皮膚在住メモリーB細胞 / 毛嚢 / 皮膚T細胞リンパ腫 / 菌状息肉症

Outline of Final Research Achievements

Barrier tissues including skin harbors a variety of resident leukocyte subsets to exert immune responses against external stimuli. They must be tightly regulated to maintain immunological homeostasis, which mechanisms have not been elucidated. In this study, we established a murine model recapitulating the cutaneous T cell lymphoma epidermotropism, which depended on the presence of hair follicle-derived cytokine. These results in pathological-state as well as the characterization of skin-resident memory B cells in steady-state, would contribute to the fundamental recognition of complex immune systems in skin.

Free Research Field

皮膚免疫学・アレルギー学