An investigation of the endophenotype of risk genes in patients with schizophrenia

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19725
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: Fujimoto Michiko 大阪大学, 医学系研究科, 特任助教(常勤) (50647625)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 統合失調症 / 眼球運動異常 / 中間表現型 / 遺伝子多型 / 生物学的精神医学

Outline of Final Research Achievements

We have previously reported that the correct rate of the discriminant analysis of 5 eye movement variables was 88% between patients with schizophrenia and healthy controls. Only 3 eye movement variables (scanpath length of free viewing task, horizontal position gain of faster lissajous task and fixation duration of far distractor task) also showed the high correct rate (82%) in the discriminant analysis between patients with schizophrenia and healthy controls. Treatment-resistant schizophrenia is thought to be one of the biomarker in the various types of schizophrenia. However eye movement variables were not different significantly when we compared patients with treatment-resistant schizophrenia to ones with not treatment-resistant schizophrenia.

Free Research Field

医歯薬学　内科系臨床医学　精神神経科学