2017 Fiscal Year Final Research Report
The role of macrophage migration inhibitory factor (MIF) in the neuroimmunological hypothesis of schizophrenia
| Project/Area Number |
15K19727
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 統合失調症 / MIF / SNP / マイクロサテライト / 死後脳 / アストロサイト / 神経幹細胞 / iPS細胞 |
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| Outline of Final Research Achievements |
We explored the role of macrophage migration inhibitory factor (MIF) in the pathophysiology of schizophrenia. We found that serum MIF level is significantly higher in patients with schizophrenia than in controls. In addition, serum MIF level is significantly positively correlated with antipsychotic dose. However, there is no difference in port-mortem brain MIF level between schizophrenia and control groups. On the other hand, we found significant association of MIF gene polymorphisms with adolescent-onset female schizophrenia. Our findings suggest that MIF is involved in the pathophysiology of schizophrenia and it might be useful for a biomarker of schizophrenia. We are going to continue the investigation of the mechanism of MIF in schizophrenia using primary mouse neural cells and human iPS cells derived from patients.schizophrenia and it might be useful for a biomarker of schizophrenia.
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| Free Research Field |
精神医学分野
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