Investigation of the glutamate hypothesis for schizophrenia using iPS cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19728
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Kobe University
• Principal Investigator: Mouri Kentaro 神戸大学, 医学研究科, 助教 (00642125)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 臨床精神分子遺伝学

Outline of Final Research Achievements

The KIF17 gene plays an important role in transport of NMDA receptors . We found that a missense SNP of KIF17 was significantly higher in schizophrenia group on the relationship between KIF 17. The protein expression of KIF17 in schizophrenic postmortem brains was significantly less than that in controls. We knocked down KIF17 gene in mouse neural progenitor cells (mNPCs) and the proliferation ability of the mNPCs was evaluated but no significant change was observed. In astrocytes treated with clozapine , KIF 17 mRNA expression were significantly decreased . For iPS cells derived from human, since it was possible to establish a system of induction of differentiation from human iPS cells to neurons, we will continue to analyze the influence on differentiation after continuing operations such as suppressing the expression of KIF17 gene .

Free Research Field

医学研究科