Mechanisms of stress response relating to medication for depressive disorder focused on microglia

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19731
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Hiroshima University
• Principal Investigator: Yamawaki Yosuke 広島大学, 医歯薬保健学研究院(歯), 助教 (90584061)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 炎症 / ストレス脆弱性 / ミクログリア / うつ病様行動 / PRIP

Outline of Final Research Achievements

The objective of this study is to elucidate the roles of phospholipase C-related catalytically inactive protein in psychological stress and inflammation-induced depression-like behavior, including anorexia focusing on microglia. Prip-deficient mice showed the vulnerability against LPS-induced anorexia. We revealed that PRIP inhibits AKT-IKK signaling in hypothalamic microglia and regulates the expression of pro-inflammatory cytokines in microglia communicating with astrocyte, which contributes to maintaining the CNS environment.

Free Research Field

薬理学