2016 Fiscal Year Final Research Report
Mechanisms of stress response relating to medication for depressive disorder focused on microglia
Project/Area Number |
15K19731
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
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Research Institution | Hiroshima University |
Principal Investigator |
Yamawaki Yosuke 広島大学, 医歯薬保健学研究院(歯), 助教 (90584061)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | 炎症 / ストレス脆弱性 / ミクログリア / うつ病様行動 / PRIP |
Outline of Final Research Achievements |
The objective of this study is to elucidate the roles of phospholipase C-related catalytically inactive protein in psychological stress and inflammation-induced depression-like behavior, including anorexia focusing on microglia. Prip-deficient mice showed the vulnerability against LPS-induced anorexia. We revealed that PRIP inhibits AKT-IKK signaling in hypothalamic microglia and regulates the expression of pro-inflammatory cytokines in microglia communicating with astrocyte, which contributes to maintaining the CNS environment.
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Free Research Field |
薬理学
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