The analysis of molecular expressions of postmortem brains with schizophrenia: genetic neuropathology

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19739
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Fukushima Medical University
• Principal Investigator: Kunii Yasuto 福島県立医科大学, 公私立大学の部局等, 准教授 (00511651)
• Research Collaborator: Yabe Hirooki 福島県立医科大学, 医学部, 教授 ; Matsumoto Junya 福島県立医科大学, 医学部, 助教 ; Hino Mizuki 福島県立医科大学, 医学部, 博士研究員 ; Wada Akira 福島県立医科大学, 医学部, 博士研究員 ; Niwa Shin-ichi 福島県立医科大学, 会津医療センター, 特任教授
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 統合失調症 / 死後脳研究 / プロテオーム / 遺伝子多型

Outline of Final Research Achievements

We performed genetic neuropathology as follows:1) the examination of protein expressions for members of the Akt signaling pathway using multiplex fluorescent bead based immunoassays in the prefrontal cortex and the nucleus accumbens of postmortem brains from 20 cases with schizophrenia, and association of these expressions with genetic variants; 2) adding 6 bipolar cases, same examination of DARPP-32 and calcineurin; 3) association study between the -141C insertion/deletion polymorphism in the dopamine D2 receptor gene and DARPP-32 expression in the striatum of schizophrenia; 4) the examination of the expressions of molecules involved in immunity and chronic inflammation using the Luminex assay in the superior temporal gyrus of post mortem brains from 60 cases including schizophrenia, and association of these expressions with genetic variants.

Free Research Field

生物学的精神医学