2018 Fiscal Year Final Research Report
The evaluation of late adverse effects of adjuvant radiotherapy using in silico sarrogate end marker
| Project/Area Number |
15K19760
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Research Collaborator |
Yoshimura Takaaki
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Keywords | 術後照射 / NTCP / 婦人科癌 / 全骨盤照射 / 乳癌術後照射 / 陽子線治療 |
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| Outline of Final Research Achievements |
IMRT and spot sccaning proton therapy(SSPT) plans were created for 13 gynecologic malignancy patients who had received hysterectomies and irradiation to the pelvic region. The Bone marrow(BM）dose using SSPT was significantly lower than with IMRT. The NTCP modeling analysis showed that the risk of grade≧3 hematologic toxicity (HT3+) using SSPT was significantly lower than with IMRT The SSPT achieves significant reductions in the dose to BM without compromising target coverage, compared with IMRT. The NTCP value for HT3+ in SSPT was significantly lower than in IMRT.
Dose volume anlaysis was carried out to eveluate the dose to the internal mammary lymph node(IMN) and normal tissure using 50 patients who reieved breaset concervation therapy(BCT).
The IMN-PTV mean doses were less than 30 Gy in all cases.The IMN dose in standard tangential irradiation for BCT is insufficient for treatment.
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| Free Research Field |
放射線腫瘍学
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| Academic Significance and Societal Importance of the Research Achievements |
婦人科癌の術後照射において、陽子線治療はX線のIMRTと比較し正常組織の線量が低減されている事が示され、更に血液毒性を低減しうる事が理論上示された。このことは陽子線治療を実際に臨床で使用する事による理論的根拠となりうる。
乳癌の術後照射において、X線で乳房と領域リンパ節に照射を行うと正常組織の線量が増大する事が示され、正常組織の線量を低減可能な照射法の考案が必要である事が示唆された。
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