2016 Fiscal Year Final Research Report
Comparative study of tau imaging tracers
| Project/Area Number |
15K19767
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 放射性医薬品 / 造影剤 / イメージング / 神経変性疾患 / 神経機能画像 |
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| Outline of Final Research Achievements |
In this study, we characterized the binding and pharmacokinetic profiles of 18F-THK5351 we developed and other reported tracer 18F-AV1451. In 18F-THK5351, radiolabeled sulfoconjugate was observed in mice and human as dominant metabolite and it showed little brain uptake, indicating its radiolabeled metabolite does not affect PET images of 18F-THK5351 in human. In addition, we found off-target binding of 18F-THK5351 was monoamine oxidase-B (MAO-B). These results suggest that 18F-THK5351 PET signal reflects tau as well as MAO-B binding. On the other hand, other off-target binding substrates of 18F-AV1451 were present, although MAO-A and melanin have been already reported. This study highlights the need for the consideration of further validation to better understand PET images using tau PET radiotracers.
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| Free Research Field |
分子イメージング
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