Development of new diagnostic method for progressive supernuclear palsy using Heavily T2-weighted 3D-FLAIR sequence

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19783
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Nagoya University
• Principal Investigator: Yamazaki Masahiro 名古屋大学, 医学部附属病院, 病院助教 (40595526)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 磁気共鳴画像法 / heavily T2強調3D－FLAIR / 放射線医学

Outline of Final Research Achievements

In this study, we showed that enhancement around the organum vasculosum of the lamina terminalis (OVLT) was observed after intravenous administration of Gadolinium-based contrast agent (GBCA) using heavily T2-weighted 3D-FLAIR sequence developed by us, and that indicated leakage of GBCAs into the CSF space with glymphatic system.
Furthermore, we showed that cochlear endolymphatic hydrops (EH) was occasionally observed in control ears using heavily T2-weighted 3D-FLAIR sequence after intravenous administration of GBCAs.

Free Research Field

放射線医学