2017 Fiscal Year Final Research Report
Prediction of erlotinib antitumor effect using 11C-Erlotinib
| Project/Area Number |
15K19797
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
OTANI Tamaki 徳島大学, 放射線総合センター, 助教 (40709557)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 11C標識エルロチニブ / EGFR遺伝子変異 / PET |
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| Outline of Final Research Achievements |
It has recently been confirmed by PET measurement for animals that erlotinib labeled with 11C which is a positron emitting radionuclide (11C-Erlotinib) specifically accumulates in a tumor in which EGFR gene mutation. However, the relationship between 11C-Erlotinib accumulation and anti-tumor effect by erlotinib has not been clarified. Therefore, the aim of this study, we evaluate that 11C-Erlotinib accumulation PET/CT imaging predict the anti-tumor effect by erlotinib using a model mouse orthotopic transplanted with an EGFR gene mutant tumor cells.
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| Free Research Field |
核医学
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