Evaluation of cellular response to proton radiation with chemotherapic agent in esophageal cancer cell lines

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19838
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: National Cancer Center Japan
• Principal Investigator: Hojo Hidehiro 国立研究開発法人国立がん研究センター, 東病院, 医員 (60638774)
• Research Collaborator: DOHMAE Takeshi ; HOTTA Kenji ; KAGEYAMA Shunichiro ; BABA Hiromi ; KOHNO Ryosuke ; MOTEGI Atsushi ; YAGISHITA Atsushi ; MAKINOSHIMA Hideki ; TSUCHIHARA Katsuya ; AKIMOTO Tetsuo
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 陽子線治療 / 生物学的効果比 / 増感剤効果比 / 拡大ブラックピーク

Outline of Final Research Achievements

To clarify the differences in the responses of cells treated with 5-FU to proton beam irradiation according to the position of the cells on the SOBP. OE21 human esophageal squamous cells were irradiated with a 235-MeV proton beam at 4 different positions on the SOBP. The degree of enhancement of the cellular sensitivity to proton beam irradiation by 5-FU was similar across all the positions on the SOBP. Furthermore, a marked increase in the number of residual γH2AX foci at 24 h post irradiation was observed in the cells at the distal end of the SOBP. Our data indicated that the degree of enhancement by 5-FU of the sensitivity of the OE21 cells to proton beam irradiation did not differ significantly depending on the position on the SOBP; however, the 5-FU-induced cytotoxicity tended to be more marked at the distal end than at other positions on the SOBP.

Free Research Field

陽子線治療