Developement and application of non-invasive input function estimation method for PET

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19840
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Iguchi Satoshi 国立研究開発法人国立循環器病研究センター, 研究所, 非常勤研究員 (60635928)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: PET / O-15 / 無採血 / 入力関数

Outline of Final Research Achievements

This study was intended to establish a noninvasive method that assess functional images from PET images acquired with sequential inhalation of 15O-oxygen and 15O-carbondioxide. Arterial input function (AIF) was obtained from PET images, by drawing regions-of-interest (ROI) on the internal carotid artery (ICA) with the recovery and spillover correction from assumed functional values in a referenced tissue area. The functional values were compared with the values from blood sampled method. While the absolute errors in the estimated functional values were mainly dependent on the errors in cerebral blood flow value of the referenced region, the difference in the relative functional values against referenced area were less than 10% in 2SD.

Free Research Field

放射線科学