Analysis of the clonal changes during neo-adjuvant chemotherapy for breast cancer and the effect on outcome of therapy.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19865
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Nagasaki University
• Principal Investigator: OIKAWA Masahiro 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (90612416)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 腫瘍内不均一性 / 乳癌 / 術前化学療法 / circulating tumor DNA

Outline of Final Research Achievements

Copy number analyses of five patients with SCC were conducted using array CGH technique. The cytogenetic profile of the SCC components indicated large intertumoral heterogeneity. There were between 2 and 160 copy number alterations per case, and no common copy number alterations were identified. The cytogenetic profiles of the paired SCC and NST components were similar but not identical. Although, in one case, a larger number of copy number aberrant regions were detected in the SCC component than the NST component. In this case, all of the NST component aberrations were present in the SCC component. This implies that the SCC component originated from the NST component. There were no common SCC-component-specific aberrations in the three NST-component cases. Our results demonstrate the cytogenetic inter- and intratumoral heterogeneity of SCC of the breast. Our comparison of cytogenetic profiles indicated that the SCC component originated from the NST component in one case.

Free Research Field

乳腺外科学