2016 Fiscal Year Final Research Report
Elucidation of the mechanism of oxidative stress damage in esophageal cancer and development of innovative treatment
| Project/Area Number |
15K19897
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 酸化ストレス / 食道癌 / MTH1 / 8-oxo-dG |
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| Outline of Final Research Achievements |
We examined the expression of MTH1 and the accumulation of 8-oxo-2'-deoxyguanosine (8-oxo-dG) in 84 patients with esophageal cancer. MTH1 mRNA expression was higher in cancerous tissues than in the corresponding normal epithelium. Immunohistochemical analysis showed that high MTH1 expression was significantly associated with deeper tumor invasion and venous invasion, advanced cancer stage, and poor overall survival and disease-specific survival compared with low MTH1 expression. Furthermore, high MTH1 expression was an independent predictor of poor disease-specific survival. In contrast, 8-oxo-dG accumulation was not associated with any clinicopathological factor and poor prognosis. These results suggest that MTH1 overexpression is a predictor of esophageal cancer progression and poor prognosis and that MTH1 can serve as a therapeutic target for treating patients with esophageal cancer.
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| Free Research Field |
消化器外科
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