Clarification the molecular mechanism of chemotherapy-related sinusoidal obstructive syndrome and the study for efficacy of anti–vascular endothelial growth factor therapy.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19898
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Kumamoto University
• Principal Investigator: KUROKI Hideyuki 熊本大学, 医学部附属病院, 非常勤診療医師 (50594876)
• Research Collaborator: HAYASHI Hiromitsu 熊本大学, 医学部附属病院, 非常勤診療医師 (80625773) ; HIGASHI Takaaki 熊本大学, 医学部附属病院, 非常勤診療医師 (70594878) ; NAKAGAWA Shigeki 熊本大学, 医学部附属病院, 特任助教 (10594872) ; YAMAMURA Kensuke 熊本大学, 医学部附属病院, 非常勤診療医師
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 大腸癌肝転移 / 肝類洞閉塞症候群 / oxaliplatin / Thrombospondin-1（TSP-1） / bevacizumab

Outline of Final Research Achievements

TSP-1 was involved in the proliferation of human umbilical vein endothelial cells (HUVEC). However, when oxaliplatin was administered to HUVEC, expression of TSP-1 was not induced. In immunostaining of TSP-1 in specimen of colorectal cancer liver metastases receiving oxaliplatin with or without bevacizumab, there was no significant difference in the expression of TSP-1 between the two groups. The possibility that the expression of TSP-1 is involved in development of SOS is low.

Free Research Field

外科腫瘍学