2016 Fiscal Year Final Research Report
Identified genetic signature stimulated peritoneal dissemination in gastric cancer
| Project/Area Number |
15K19899
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University (2016)
Kumamoto University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 胃癌 / 腹膜播種 / コラーゲン / DDR2 / PLOD2 |
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| Outline of Final Research Achievements |
Molecular mechanisms driving peritoneal dissemination still remain poorly understood. Here, we aimed to provide novel insights into the molecular mechanisms that drive the peritoneal dissemination of GC. We performed combined expression analysis with in vivo-selected metastatic cell lines and samples from 200 GC patients to identify driver genes of peritoneal dissemination. We identified a peritoneal dissemination-associated expression signature, whose profile correlated with those of genes related to development, focal adhesion, and the extracellular matrix. Among the genes comprising the expression signature, we identified that genes (DDR2 and PLOD2) as a potential regulator of peritoneal dissemination. These three gene were identified as a driver gene for GC dissemination from the combined expression signature and can potentially serve as a novel therapeutic target for inhibiting GC peritoneal dissemination.
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| Free Research Field |
消化器外科学
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