2016 Fiscal Year Final Research Report
Functional analysis of cell cycle-related protein BubR1 in intimal hyperplasia lesions
| Project/Area Number |
15K19924
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Research Collaborator |
TANAKA Shinichi
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 動脈硬化 / 内膜肥厚 / BubR1 |
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| Outline of Final Research Achievements |
【Background】BubR1 is a cell cycle-related protein. We generated BubR1L/L-ApoE-/- mice to examin the role of BubR1 in arteriosclerosis.【Methods and Results】The arteriosclerotic lesion was significantly suppressed in BubR1L/L-ApoE-/- mice and the accumulation of macrophages was decreased as compared with ApoE -/- mice. Bone marrow-derived cells and non-bone marrow-derived cells of BubR1 were involved in suppression of arteriosclerosis. There was no significant difference in the migratory ability of bone marrow-derived macrophages, but the proliferative capacity was decreased in BubR1L/L-ApoE-/- mice. 【Conclusions】BubR1 may be a target for new treatments to suppress arteriosclerosis.
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| Free Research Field |
血管外科
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