2016 Fiscal Year Final Research Report
Integrated analysis of metabolomics and genetics using cerebrospinal fluid of glioma patients
| Project/Area Number |
15K19970
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | メタボローム解析 / グリオーマ / IDH変異 / 2HG |
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| Outline of Final Research Achievements |
Using gas chromatography/mass spectorometry, metabolome analysis of cerebrospinal fluid of 53 patients was performed。And isocitrate dehydrogenase (IDH) mutation of the tumor was examined. The mean concentration of 2-hydroxygulitarate (2HG) in the CSF was 0.48mM. The mean concentration of 2HG in glioblastoma, anaplastic astrocytoma, diffuse astrocytoma, and olifodendroglioma were 0.41mM, 0.46 mM, 0.71 mM, and 0.49 mM, respectively. There was no significant difference among tumor pathology. There were 11 cases with IDH mutation. In IDH mutation group, the mean concentration of 2HG was 0.61±0.2mM, on the other hand, in IDH wild-type group, the mean concentration of 2HG was 0.44±0.06mM. There was no significant difference of 2HG concentration between IDH mutation group and IDH wild-type group. These results indicate that 2HG concentration of CSF is not useful biomarker for the glima patients.
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| Free Research Field |
脳腫瘍
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