2016 Fiscal Year Final Research Report
Development of novel therapy targeting for B7 family on glioma cancer stem cells
| Project/Area Number |
15K19983
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
|
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| Research Institution | Kansai Medical University |
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Principal Investigator |
IWATA Ryoichi 関西医科大学, 医学部, 助教 (60580446)
|
|---|
| Research Collaborator |
Nakano Ichiro
|
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | グリオーマ / 癌幹細胞 / 免疫治療 |
|---|
| Outline of Final Research Achievements |
This study is aimed to reveal the role of ICOS ligand in glioblastoma development. We have revealed that mesenchymal type glioma cancer stem cells express the ICOS ligand. Expression of ICOS ligand is associated with poor prognosis. Moreover, ICOS ligand promote the expansion of IL-10 producing T cells in the tumor microenvironment.
|
| Free Research Field |
医歯薬学
|
