Elucidation of novel bone matrix regulatory system by collagens VI and XII.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19988
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Chiba Institute of Science (2016); Tokyo Medical and Dental University (2015)
• Principal Investigator: Izu Yayoi 千葉科学大学, 危機管理学部, 講師 (90431949)
• Research Collaborator: AIDA Tomomi Massachusetts Institute of Technology, Research Scientist ; BIRK David E. University of South Florida, Professor ; KOCH Manuel University of Cologne
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: VI型コラーゲン / XII型コラーゲン / 骨形成 / 骨芽細胞 / 骨芽細胞ネットワーク

Outline of Final Research Achievements

In this research, we aimed to elucidate the control mechanism of bone quality, focusing on regulation of bone forming osteoblast cell-cell communication. We have elucidated that lack of collagen VI or collagen XII induces osteoblast shape change thereby decreased bone quality. In this research, we found that cooperative regulation of collagens VI and XII form osteoblast cell-cell communication network.

Free Research Field

骨生理学、細胞生物学