2017 Fiscal Year Final Research Report
Analysis of micro RNA related to osteosarcoma metastasis
| Project/Area Number |
15K20009
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Tome Yasunori 琉球大学, 医学(系)研究科(研究院), 准教授 (20547369)
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| Research Collaborator |
Kiyuna Tasuku 琉球大学, 医学研究科, 大学院生
Oshiro Hiromichi 琉球大学, 医学研究科, 大学院生
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | miRNA / 骨肉腫 / 肺転移 |
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| Outline of Final Research Achievements |
Total RNAs including micro RNAs were extracted from parental human osteosarcoma 143B cells and highly metastatic 143B-LM4 cells. mir-143 and mir-145 were higher expressed in 143B-LM4 cells compared to 143B cells. Moreover, DNA microarray analysis was performed using extracted RNAs. TANGLM and LASP1, which are related to mir-143 and mir-145, were highly expressed. Further analysis would be performed with 143B cells and 143B-LM4 cells regarding TANGLM and LASP1.
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| Free Research Field |
整形外科, 骨・軟部腫瘍
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