2016 Fiscal Year Final Research Report
Involvement of opioid receptor family in the analgesic action of NMDA receptor antagonists
| Project/Area Number |
15K20043
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | NMDA受容体 / 亜酸化窒素 / キセノン / ケタミン / オピオイド受容体 |
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| Outline of Final Research Achievements |
It has been shown that the nociceptin receptor is involved in the analgesic action of nitrous oxide, and that the analgesic action of nitrous oxide in the mu-opioid receptor knockout mice is not significantly different from that in the wild-type mice. In this study, we have analyzed the analgesic action of nitrous oxide in the kappa-opioid receptor knockout mice. It was demonstrated that the analgesic action of nitrous oxide was almost completely lost in the kappa-opioid receptor knockout mice. In contrast, the sedative action of nitrous oxide, which was estimated by loss of righting reflex, was not significantly different between kappa-opioid receptor knockout mice and wild-type mice. These results suggest that the analgesic action and the sedative action of nitrous oxide are mediated by different mechanisms.
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| Free Research Field |
麻酔科学
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