Can detrusor overactivity induce detrusor underactivity independently of atherosclerosis in rats?

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20080
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: University of Fukui
• Principal Investigator: SEKI Masaya 福井大学, 学術研究院医学系部門, 助教 (70572444)
• Research Collaborator: NAGASE Keiko 福井大学, 教務補佐員 ; ZHA Xinmin 福井大学, 教務補佐員
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 過活動膀胱 / 膀胱血流 / 低活動膀胱

Outline of Final Research Achievements

Decreased blood flow due to atherosclerosis is considered to induce detrusor overactivity (DO) and later detrusor underactivity (DU). We examined the possibility that DO induces DU independently of atherosclerosis in a rat model of DO.
DO was induced by 4-week continuous intravesical infusion of carbachol (CCh). The CCh infusion induced frequent voiding and decreased voided volume. The strength of the contraction of bladder strip per tissue weight by high-potassium, CCh or electrical field stimulation was reduced in rats with CCh intravesical infusion compared to control rats. It is possible that DO induces DU independently of atherosclerosis.

Free Research Field

医歯薬学