The importance of regulation of the tumor microenvironment in cisplatin-resistant urothelial carcinoma

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20110
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Keio University
• Principal Investigator: Niwa Naoya 慶應義塾大学, 医学部(信濃町), 助教 (40626743)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 尿路上皮癌 / 癌微小環境 / 上皮間葉転換 / シスプラチン / 抗癌剤耐性

Outline of Final Research Achievements

Knockdown and overexpression of TNF-alpha induced protein 2 (TNFAIP2) in 5637 and its subline 5637PR with acquired platinum resistance resulted in suppression and overexpression of epithelial-mesenchymal transition related proteins, respectively. Immunohistochemical analysis in surgical specimens revealed that the expression of TNFAIP2 is significantly associated with oncologic outcome in patients with urothelial carcinoma. Moreover, overexpression and suppression of TNFAIP2 resulted in promotion and inhibition of cancer cells, respectively. These results suggested the importance of the regulation of the tumor microenvironment by targeting TNFAIP2 and its potential as a new therapeutic target.

Free Research Field

尿路悪性腫瘍