2017 Fiscal Year Final Research Report
New challenge aiming at peritoneum development control of ovarian cancer by targeted new EMT transcriptional factor
| Project/Area Number |
15K20136
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Fujita Health University (2017)
Nagoya University (2015-2016) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | PLAGL2 / 卵巣癌 / RhoA / Rac1 / CHN1 / 抗癌剤耐性 |
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| Outline of Final Research Achievements |
PLAGL2(Pleimorphic adenoma gene like-2),a member of the PLAG gene family, is a C2H2 zinc-finger transcriptional factor that is involved in cellular transformation and apotosis.I found out that a change is also admitted in actin stress fiber and cell chemotactic activity in PLAG1 and PLAGL1 which are a homolog gene of PLAGL2.A possibility that several genes participate in a cell mortal lead mechanism of PLAGL2 in a DNA micro array analysis was suggested.
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| Free Research Field |
婦人科腫瘍学
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