The nobel cancer treatment of non-thermal plasma inhibits EMT and peritoneal metastasis of ovarian cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20137
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Nagoya University
• Principal Investigator: UTSUMI Fumi 名古屋大学, 医学部附属病院, 助教 (10749261)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 大気圧プラズマ / 卵巣癌 / 腹膜播種 / 化学療法耐性 / EMT

Outline of Final Research Achievements

In this research we examined the effect and mechanisms of cytotoxicity of plasma-activated medium (PAM) using ovarian cancer cells. Especially we focused on the chemo-resistant ovarian cancer cells. PAM treatment prolongs longevity in an ovarian cancer mouse model. Intraperitoneal PAM injection was applied in a mouse model of intraperitoneally injected with ES2 cells. The survival rates were better in the PAM treatment group than in the control group. Furthermore, using the IVIS imaging system, it was suggested that peritoneal metastatic was significantly inhibited by PAM, although the omentum showed no obvious recovery. PAM inhibited invasion and migration by repressing MMP-9 expression. In this research, PAM exerted the effect by inhibiting the phosphorylation of INK1/2 and p38.

Free Research Field

婦人科腫瘍