Genetic testing for HBOC-related gene mutation provides important risk information for ovarian cancer patients in Japan

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20148
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokushima
• Principal Investigator: ABE Akiko 徳島大学, 大学院医歯薬学研究部(医学系), 助教 (30748588)
• Research Collaborator: IMOTO Issei
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 卵巣癌 / 遺伝性腫瘍 / 遺伝子パネル検査

Outline of Final Research Achievements

We investigated the awareness survey and the rate of 11 genes including gBRCA1/2 mutation with ovarian cancer. After genetic counselling, 124 of 127 patients with ovarian cancer consented of analysis. For 108 patients, analyses for gBRCA1/2 test were performed. 80% wished for gBRCA1/2 result disclosure, and germline gene mutation was identified in 15.7%. Almost patients with ovarian cancer patients wanted to know genetic risk after genetic counselling. We are planning to develop a surveillance system that includes relatives.

Free Research Field

婦人科腫瘍　遺伝性腫瘍