The development of new treatment for endometriosis using non hormone therapy targeting intraperitoneal environment.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20152
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Kumamoto University
• Principal Investigator: ITOH Fumiko 熊本大学, 医学部附属病院, 助教 (90648271)
• Co-Investigator(Renkei-kenkyūsha): KATABUCHI Hidetaka 熊本大学, 大学院生命科学研究部産科婦人科学, 教授 (90224451) ; HONDA Rituo 熊本大学, 大学院生命科学研究部産科婦人科学, 講師 (10301376)
• Research Collaborator: TUBOKI Junko 熊本大学, 医学部附属病院 地域医療・総合診療実践学寄付講座 (70772408)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 子宮内膜症 / 腹腔マクロファージ / 子宮内膜間質細胞

Outline of Final Research Achievements

The results of the cytokine array showed up-regulated IL-1β, IL-2, IL-8, IP-10, MIP-1β, RANTES, TNF-α and sTREM-1 production in ascites of endometriosis patients. GM-CSF and GM-CSF receptor mRNAs were expressed on macrophages and ESCs, and GM-CSF significantly and dose-dependently induced ESCs proliferation. GM-CSF may be associated with interaction between ESCs and macrophages in development of endometriosis. Corosolic acid, a triterpenoid compound, inhibited ESC proliferation and Stat3 activation. Targeting Stat3 signals or the regulation of macrophage function may aid the treatment of patients with endometriosis.

Free Research Field

産科婦人科学