The elucidation of pathogenetic mechanism in allergic rhinitis

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20193
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: University of Fukui
• Principal Investigator: Kato Yukinori 福井大学, 学術研究院医学系部門(附属病院部), 助教 (00748981)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: アレルギー性鼻炎 / Local Allergic Rhinitis / 局所IgE / 活性化Th2細胞 / ILC2s / 好酸球 / ブタクサ花粉

Outline of Final Research Achievements

In this study, we established a novel murine model of AR by serial nasal sensitization of ragweed without inducing prior systemic atopy.
Serial nasal sensitization of ragweed pollen induced an allergen-specific increase in sneezing, eosinophilic infiltration, and the production of local IgE by day 7, but serum antigen-specific IgE was not detected. Th2 cells accumulated in nose and cervical lymph nodes as early as day 3. These symptoms are characteristic of human local allergic rhinitis (LAR). Mice repeatedly exposed to the allergen through the nasal route evolved systemic atopy. Because the emergence of local Th2 cells is the first detectable sign and they have a central role in disease pathogenesis, T-cell-based diagnosis and therapy may improve LAR treatment.

Free Research Field

アレルギー性鼻炎