Explication of branch retinal vein occlusion and establishment of new drug therapy using Doppler OCT flowmeter

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20242
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Asahikawa Medical College
• Principal Investigator: TANI Tomofumi 旭川医科大学, 大学病院, 助教 (90466491)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: DOCT血流計 / 大動脈炎症候群 / 動静脈交叉部

Outline of Final Research Achievements

Following basis and clinical study were performed for retinal circulation using Doppler OCT flowmeter developed in conjunction with TOPCON JAPAN Corporation.(1)in vitro in glass capillary and in vivo in anesthetized cats:To make sure of the measurement accuracy of the DOCT flowmeter, we checked the reproducibility experiment of blood velocity of the glass capillary and anesthetized cats.(2)Clinical study:First, we performed a study for check reproducibility and repeatability in human subjects. Second, we evaluated the retinal microcirculation in a patient with Takayasu's arteritis (TA) with aortic valve regurgitation (AR). The study showed for the first time that DOCT flowmeter enables evaluation of an abnormal flow pattern of the retinal blood velocity profile in the retinal arterioles in a patient with TA and AR.In addition, we measured retinal venous circulation at before and after arterio-venous crossing in branch retinal vein occlusion patients.

Free Research Field

眼科学