2016 Fiscal Year Final Research Report
The application to the treatment of intraocular peroxisome proliferator-activatedreceptor gammma in patients with proliferative diabetic retinopathy.
| Project/Area Number |
15K20265
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 糖尿病網膜症 / VEGF / PPARγ |
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| Outline of Final Research Achievements |
The PPARγ concentrations in the aqueous humor and vitreous fluid were significantly higher in PDR patients than in controls (P<0.0005). There was a significant positive correlation between the PPARγ and VEGF concentrations (P<0.0005). The level of PPARγ increased as the clinical stage advanced. The expressions of the mRNA and protein of PPARγ were higher in the membranes of PDR than those of controls. Anti-VEGF therapy significantly reduced the VEGF concentration (P<0.0001) but not the PPARγ concentration. PPARγ may play an important role and a therapeutic target in the pathogenesis of PDR.
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| Free Research Field |
網膜硝子体疾患
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