2016 Fiscal Year Final Research Report
Protective effects of lutein in tight junction disruption that promotes progression of age-related macular degeneration
| Project/Area Number |
15K20283
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 網膜 / 加齢黄斑変性 / 抗酸化酵素 / タイトジャンクション / ルテイン |
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| Outline of Final Research Achievements |
Photo-induced disruption of tight junction in the retinal pigment epithelium was recovered only slowly. However, lutein administration reduced tissue ROS levels and promoted the recovery. Lutein prolonged photo-induced mRNAs of antioxydative enzymes, SOD1 and SOD2, and SOD activity. Tissue mRNA levels of a photo-induced inflammatory cytokine, MCP-1, was suppressed by lutein. Similar effect was observed in ARPE19 cell line. Lutein promoted recovery of disrupted tight junction reducing oxidative stress most likely by both scavenging ROS and inducing antioxydative enzymes.
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| Free Research Field |
網膜
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