2016 Fiscal Year Final Research Report
The analysis of the interaction between gut microbiota, metabolite and intestinal immune response with integrative comics approach
| Project/Area Number |
15K20339
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 腸内フローラ / マルチオミクス手法 / 免疫応答 / IgA / メタボローム解析 / 水素 / 重症病態 |
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| Outline of Final Research Achievements |
Microbiota composition is altered in the critical illnesss, leading to dysregulated intestinal or systemic immune responses. However, the mechanism is not well established. We aimed to analyze the interaction between gut microbiota, metabolite and intestinal immune response with integrative omics approach in a murine model of sepsis. We revealed the rapid and dynamic alterations of gut microbiota, metabolite in murine septic mice. In particular, the dramatic overgrowth of Enterobacteriaceae, which was specifically combined with sIgA, would be a key bacteria for therapeutic strategy. Furthermore, we found the potential effect of hydrogen-rich saline with improving the survival rate and attenuating the overgrowth of Enterobacteriaceae.
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| Free Research Field |
救急、集中治療
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