Molecular basis of regenerative therapy for musculoskeletal system using mechanical stress

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20375
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Functional basic dentistry
• Research Institution: Kagoshima University
• Principal Investigator: KUSUYAMA Joji 鹿児島大学, 医歯学総合研究科, 客員研究員 (70596105)
• Research Collaborator: MATSUGUCHI Tetsuya ; OHNISHI Tomokazu ; BANDOW Kenjiro ; SEMBA Ichiro ; SHIMA Kaori ; KAJIYA Yuka
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: メカニカルストレス / 間葉系幹細胞 / 骨芽細胞 / 脂肪細胞 / オステオポンチン / Syk

Outline of Final Research Achievements

Mechanical stress is physical stimulation that applies to cells and tissues in our body. Musculoskeletal system system is one of the representative organ which are usually affected by mechanical stress. Previously, we showed that mechanical stress can regulate the multi-differentiation of mesenchymal stem cells. The goal of this study is to establish the molecular-based therapy to induce the maintenance and regeneration of musculoskeletal system by mechanical stress application. We found that physiological response to mechanical stress in osteoblasts is clearly changed in the stage of osteogenenic differentiation. We also found the novel signaling molecule to control the initial stage of mesenchymal stem cell differentiation into osteoblasts and adipocytes.

Free Research Field

分子生物学、口腔生化学