Proteomic analysis of cell competition in the lateral invasion front of oral squamous cell carcinoma

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20384
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Niigata University
• Principal Investigator: ABE Tatsuya 新潟大学, 医歯学総合研究科, 特任助教 (70634856)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 口腔扁平上皮癌 / 細胞競合 / プロテオミクス

Outline of Final Research Achievements

Oral squamous cell carcinoma (SCC) and carcinoma in-situ (CIS) frequently form the interface facing non-cancerous epithelium. I hypothesized cell competition might be occurred between cancer and non-cancerous cells in this interface. Thus, I investigated this interface histopathologically and performed proteomic analysis using LC-MS/MS. In histological analysis, apoptotic bodies, hyaline bodies, and other morphological changes suggesting cell damage were frequently observed in the cancer side adjacent to the interface. From proteomic analysis, 7 proteins, specifically increasing or decreasing in the cancer or non-cancerous sides adjacent to the interface, were identified. These proteins may be involved in cell competition between oral SCC/CIS cells and non-cancerous cells.

Free Research Field

病理学