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2017 Fiscal Year Final Research Report

Identification of the target genes involved in epigenetics with the infection of the oral epithelium

Research Project

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Project/Area Number 15K20389
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

Yoshida Koki  北海道医療大学, 歯学部, 助教 (30453260)

Project Period (FY) 2015-04-01 – 2018-03-31
Keywordsエピジェネティクス
Outline of Final Research Achievements

The purpose of this study was to identify the target genes involved in the periodontal disease and oral mucosal diseases. The present results indicate that DNA methylation levels of Fibroblast growth factor receptor3 (FGFR3), Caspase2 (CASP2) and Cell division cycle 25B (CDC25B) were significantly changed stimulated with periodontal pathogens toxin. From the above, periodontal pathogens toxin may affect cell cycle with inflammatory reaction.

Free Research Field

臨床口腔病理学

URL: 

Published: 2019-03-29  

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