Identification of the target genes involved in epigenetics with the infection of the oral epithelium

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20389
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: Yoshida Koki 北海道医療大学, 歯学部, 助教 (30453260)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: エピジェネティクス

Outline of Final Research Achievements

The purpose of this study was to identify the target genes involved in the periodontal disease and oral mucosal diseases. The present results indicate that DNA methylation levels of Fibroblast growth factor receptor3 (FGFR3), Caspase2 (CASP2) and Cell division cycle 25B (CDC25B) were significantly changed stimulated with periodontal pathogens toxin. From the above, periodontal pathogens toxin may affect cell cycle with inflammatory reaction.

Free Research Field

臨床口腔病理学