2017 Fiscal Year Final Research Report
Study on residual ridge resorption by the mechanical stimulation for residual ridge maintenance in prosthetics
Project/Area Number |
15K20440
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Prosthodontics/ Dental materials science and
|
Research Institution | Okayama University |
Principal Investigator |
ARAKI DAISUKE 岡山大学, 医歯薬学総合研究科, 助教 (90733303)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Keywords | 機械的刺激 / メカニカルストレス / 歯肉繊維芽細胞 |
Outline of Final Research Achievements |
Mechanical stress is known to be important for regulation of bone turnover, though the detailed mechanisms are not fully understood. We previously reported that osteoclastic bone resorption under the denture base has been influenced by mechanical force exerted through the denture base. The present study was undertaken to examine the effect of mechanical stress on the production of cytokines using rat gingival fibroblasts isolated from the palate and to examine the indirect effect of mechanical stress on osteoclast differentiation using RAW 264.7 cells as osteoclast precursors. It was revealed that cyclic compressive force promoted production of PGE2 and induced osteoclast differentiation in rat gingival fibroblasts
|
Free Research Field |
歯科補綴学
|