Development of scaffolds to support mesenchymal stem cells for tissue engineering

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20472
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: NAKAMURA Miho 東京医科歯科大学, 生体材料工学研究所, 准教授 (40401385)
• Co-Investigator(Renkei-kenkyūsha): YAMASHITA Kimihiro 東京医科歯科大学, 生体材料工学研究所, 教授 (70174670) ; HORIUCHI Naohiro 東京医科歯科大学, 生体材料工学研究所, 助教 (90598195)
• Research Collaborator: LEHENKARI Petri University of Oulu, Professor ; TUUKKANEN Juha University of Oulu, Professor
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 生体材料 / 間葉系幹細胞 / 破骨細胞 / 有機無機コンポジット

Outline of Final Research Achievements

The aim of this study is to develop the scaffolds for regenerative medicine to support the functions of mesenchymal stem cell. The osteoclast differentiation from monocytes were induced on the organic (PLA) and inorganic (hydroxyapatite, carbonate apatite and βtricalcium phosphate) composites with more inorganic materials and enhanced by co-culture with mesenchymal stem cells. The mesenchymal stem cells inhibited the inflammation in vivo. These results suggest that the composites would be useful and helpful in tissue regeneration as a scaffold.

Free Research Field

生体材料学