2016 Fiscal Year Final Research Report
Development of prevention and repair of degenerative joint disorders with fluocinolone acetonide (FA).
| Project/Area Number |
15K20480
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Research Collaborator |
KUBOKI Takuo (00225195)
ONO Mitsuaki (60613156)
Emilio Satoshi Hara (40779443)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | フルオシノロンアセトニド / 軟骨細胞分化 / 軟骨再生 / ヒト骨髄由来間葉系間質細胞 |
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| Outline of Final Research Achievements |
Osteoarthritis is the most common chronic condition of the joints, affecting approximately ten million Japanese and articular cartilage repair remains a challenging problem. Based on a high-throughput screening and functional analysis, we found that fluocinolone acetonide (FA) strongly potentiated chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs). In an in vivo cartilage defect model in knee joints of immunocompromised mice, transplantation of FA/TGF-b3 -treated hBMSCs could completely repair the articular surface.
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| Free Research Field |
骨組織および軟骨組織などの硬組織の再生医療のトランスレーショナルリサーチ
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