Elucidation of oral cancer carcinogenesis mechanism from a microRNA perspective

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20501
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: University of Tsukuba
• Principal Investigator: UCHIDA Fumihiko 筑波大学, 附属病院, 医員 (70736008)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: microRNA / 口腔がん / 発癌

Outline of Final Research Achievements

In this study, I investigated whether leukoplakia can be distinguished by miRNA expression levels. microRNA microarray profiling was used to compare microRNA expression in 5 formalin-fixed, paraffin-embedded (FFPE) leukoplakia resected specimen. Some microRNAs exhibited statistically significant differences in expression between the leukoplakia, normal oral mucosal epithelium and oral cancer samples. microRNA expression profiles in leukoplakia may potentially be used to identify oral cancer carcinogenesis mechanism, and microRNAs that are up-regulated in leukoplakia may be targets for therapeutic intervention.

Free Research Field

外科系歯科学