2017 Fiscal Year Final Research Report
Development of new strategy for jaw deformity using CNP
| Project/Area Number |
15K20516
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | CNP / 顎変形症 / 内軟骨性骨化 |
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| Outline of Final Research Achievements |
Analysis of the μCT image of achondroplasia (Ach) model mice revealed midfacial hypoplasia in the sagittal direction and foramen magnum stenosis similarly to human. Both hypertrophic chondrocyte layers and proliferating chondrocyte layers the cartilage of the skull base of the Ach mice were narrowed, and early ossification with angiogenesis and apoptosis was found in the center of the cartilage of the skull base. The midfacial hypoplasia and the foramen magnum stenosis in the Ach mice could be significantly improved by the increase in the blood concentration of CNP.
It was suggested that administration of CNP could improve the abnormalities of craniofacial morphology found in achondroplasia by promoting endochondral ossification in the cranial cartilage.
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| Free Research Field |
口腔外科学
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