2017 Fiscal Year Final Research Report
Transcutaneous carbon dioxide induces suppresses metastasis of oral squamous cell carcinoma
| Project/Area Number |
15K20521
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kobe University |
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Principal Investigator |
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| Research Collaborator |
IWATA Eiji
TAKEDA Daisuke
UEHA Takeshi
SAKAI Yoshitada
KOMORI Takahide
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 炭酸ガス / 口腔癌 / 扁平上皮癌 / 転移 |
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| Outline of Final Research Achievements |
We previously demonstrated that transcutaneous CO2 suppresses the growth of primary human OSCC and metastasis to the regional lymph nodes by both improving hypoxia and increasing mitochondrial apoptosis in treated tissue. Therefore, we hypothesized that improving hypoxia by transcutaneous CO2 could suppress EMT. In the present study, we investigated whether oxygen conditions affect HIF-1α and EMT factors in OSCC in vivo and whether transcutaneous CO2 affects these factors in OSCC. In the present study, in vivo studies revealed that transcutaneous CO2 increased E-cadherin expression with the decreased expression of HIF-1α, Snail, Slug, N-cadherin, and Vimentin in treatment tumors. These results suggest that transcutaneous CO2 could suppress EMT by improving hypoxia, resulting in the reduction of metastatic potential of OSCC. The findings indicate that transcutaneous CO2 may be able to improve the prognosis of OSCC patients through the suppression of EMT.
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| Free Research Field |
口腔外科学
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