Analysis of characteristics of lymphatic microcirculation within metastatic lymph nodes focusing on endothelial cell junctional complex

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K20522
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kobe University
• Principal Investigator: Akashi Masaya 神戸大学, 医学研究科, 講師 (40597168)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: 口腔癌 / リンパ管 / 放射線治療 / リンパ節転移

Outline of Final Research Achievements

The effects of radiation on morphology, cell integrity, and permeability of lymphatic endothelial cells were analyzed for a better understanding of relationship between cancer and lymphatic vessels. As a result, changes in lymphatic endothelium were found under the influence of radiation, which could contribute to an understanding of the onset mechanism of complications such as lymph node metastasis of cancer and lymphedema after radiation.

Free Research Field

口腔外科学

Academic Significance and Societal Importance of the Research Achievements

本研究によりリンパ浮腫発症因子や増悪因子がリンパ管内皮細胞間接着に対しどのような構造的変化を及ぼすかが解明され、さらに、この構造的変化をリバースさせ得る薬剤を網羅的に検討することで、今後リンパ浮腫の根治療法確立に向け大きく前進することが期待される。