2017 Fiscal Year Final Research Report
application of targeted drug into super selective intraarterial chemotherapy on oral cancer
| Project/Area Number |
15K20550
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 口腔癌治療 |
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| Outline of Final Research Achievements |
To develop the optimized chemotherapy, we investigate the several combination of chemo-drugs including cetuximab and different routes of drug administration. We determined the anti-tumor effect of docetaxel and cetuximab with or without combination using different routes including intratumoral (IT) as locally and intraperitoneal (IP) as systemic administration. Co-administration of cetuximab (IP) and docetaxel (IT) showed the highest anti-tumor effect and decreased density of microvessel in tumor. Although administration of docetaxel induced the influx of CD11b+ cells, IP administration of cetuximab inhibited the recruitment of CD11b+ cells that may contribute to neovasculogenesis.
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| Free Research Field |
口腔癌
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