Development of Photodynamic Hyperthermia Therapy using ICG for oral cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20551
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Yokohama City University
• Principal Investigator: IIDA Masaki 横浜市立大学, 医学部, 助教 (70613511)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 口腔癌 / インドシアニングリーン / 温熱療法 / 光線力学療法

Outline of Final Research Achievements

The purpose of this study is to develop photodynamic hyperthermia therapy (PHT) by superselective intra-arterial infusion method using ICG as a new cancer treatment strategy applicable to superselective intra-arterial chemoradiotherapy . It is known that ICG generates heat by light irradiation. ICG is administered to the tumor feeding artery by using superselective intra-arterial infusion method, and it is accumulated at a high concentration in the tumor tissue. This method may improve the therapeutic effect of hyperthermia and photodynamic therapy.
In this study, animal experiments using nude mice subcutaneous tumor model suggest that forceful antitumor effect in PHT by ICG using superselective intra-arterial infusion method is obtained, which can be a promising treatment for oral cancer.

Free Research Field

口腔癌